Medically reviewed by Jessica Swirble, PharmDLast updated on April 2, 2025
Drug Information| | |
Baclofen is a selective gamma-aminobutyric acid (GABA) receptor agonist that is used to treat muscle and pain caused by central nervous system disorders such as multiple sclerosis, spinal cord injuries, or Parkinson’s disease. It works by helping to increase the levels of a neurotransmitter called GABA.
Baclofen is also used to treat symptoms of alcohol and substance abuse. It can be prescribed to people with alcoholism, abuse, or substance abuse problems to help reduce the chances of success in successfully quitting tobacco and alcohol use disorder. Baclofen is only approved for use by doctors.
The dosage of baclofen can vary depending on the condition being treated, the severity of pain and the severity of the patient's alcohol and drug use disorder. It's important to follow the instructions provided by your healthcare provider regarding the use of baclofen.
The effects of baclofen can last from 4 to 12 weeks, although it may be prescribed once daily as a short-term treatment for pain and muscle weakness. However, it's important to continue using baclofen as prescribed to help ensure you're getting the best results from your treatment.
The most common side effects of baclofen are sedation, dry mouth, constipation, dizziness, and headache. These symptoms should be reported to your doctor or healthcare provider if you have any concerns.
The most common side effects of baclofen are sedation, sedation, dizziness, and headache. Serious but rare side effects include nausea, vomiting, stomach pain, and seizures. The symptoms of baclofen-induced seizures are also not common, but may require dosage adjustments or surgery.
Baclofen should not be used by individuals with a history of liver disease, kidney disease, heart disease, asthma, or trouble sleeping. It's important to tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, herbal medicines, and recreational drugs.
Before starting baclofen treatment, tell your healthcare provider if you have liver or heart disease, diabetes, high cholesterol, high blood pressure, a history of alcohol or drug abuse, or a history of seizures or diabetes. Baclofen should not be used by individuals who are taking any medication for any condition.
Baclofen can interact with other medications and substances, causing side effects. If you are taking any medications and were previously diagnosed with a mental health condition, such as depression or anxiety, inform your healthcare provider if you are taking any medications.
Baclofen can interact with other drugs and substances, causing side effects. If you are taking any medications and were previously diagnosed with anxiety or mood disorders, such as panic, notice any changes or mental health symptoms without also taking any medications for anxiety or depression.
Baclofen may make some medications come with a warning label change. It's best to read the leaflet that comes with your medication, especially if it's from a health professional. This may contain information that could be dangerous.
Be aware of uncommon side effects that can occur with baclofen. If you notice any of the following symptoms, stop taking baclofen and contact your healthcare provider immediately: suicidal thoughts, behavior, or thoughts of self-harm, if any.
Managing side effects of baclofen can be a challenging process. However, BACLOFEN is an effective medication for managing these and other side effects associated with baclofen. Here are some strategies to help manage side effects:
Baclofen is used to treat muscle spasms caused due to cerebral palsy, multiple sclerosis, stroke or due to any other nerve or spinal cord disorders.
Baclofen: Muscle Relaxants
Baclofen is a muscle relaxant. It acts by increasing the effects of certain chemical messengers (such as GABA) in the spinal cord that induces muscle relaxation. As a result, it prevents muscle twitching, relieves pain caused due to muscle spasms and improves muscle movement.
Consult your doctor:
compel the doctor to perform an initial consultation with a medical professional and a tailored treatment plan is taken in to account. This approach helps mitigate potential risks related to Baclofen, allowing for tailored treatment with tailored results. The doctor may also monitor your nyst Required dosage as it provides guidance on dosage and adjusting as necessary. Your doctor will discuss any potential side effects and adjust the dosage accordingly. This approach helps minimise the risk of serious side effects related to the drug, such as allergic reactions, which are rare but require immediate medical attention. Your doctor will consider your medical history, your experience and the specific circumstances of any desired reactions to ensure your well being is maintained.
Baclofen should be taken exactly as prescribed by your doctor. Ensure the tablet is taken with food to avoid stomach upset. Do not take this medicine if you are taking an anti-seizure medication or if you have a history of hypersensitivity to Baclofen or any of the ingredients in this medicine.
Baclofen (BAL), a widely used drug for muscle and nervous system disorders, is a centrally acting agent. To date, there are no reports of its use in spasticity. In this study, we attempted to determine whether baclofen could improve spasticity associated with cerebral palsy (CP). The study was designed to assess the efficacy and safety of baclofen for the treatment of CP. A total of 150 participants with CP and 150 participants with spasticity (BAL-CP) were enrolled. Participants were randomly assigned to baclofen (0.5 mg/kg b.i.d., spastic dystonic dystonic muscle disorder) or a placebo group. The treatment group received oral baclofen (60 mg/day) for the first time (30 minutes) and oral baclofen (60 mg/day) for the following six weeks. The spasticity scores in the baclofen group were significantly improved compared with the placebo group. In addition, baclofen significantly reduced the incidence of dystonic dystonic dystonic movements. The most important adverse events of baclofen were somnolence and headache. Our study indicates that baclofen may be a suitable alternative for the treatment of spasticity associated with CP.
Citation:Chen J, Zhou Y, Yu Y, Gu J, Liu J, Li Y, Li J, et al. (2018) Effect of baclofen on spasticity associated with CP on movement disorders in children with cerebral palsy. PLoS ONE 16(5): e0183021. https://doi.org/10.1371/journal.pone.0183021
Editor:Wenzhe Weng, Children's Hospital of Yonsei University, Taiwan
Received:February 4, 2018;Accepted:June 28, 2018;Published:July 4, 2018
Copyright:© 2018 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding:This study was funded by the National Natural Science Foundation of China (grant no. 31572070), and the Natural Science Foundation of Shanghai, China (grant no. 10H142100). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests:The authors have declared that no competing interests exist.
Spasticity is a common neurological disorder that causes substantial disability and disability-for-profit care. This disorder can lead to significant disability, including significant neurological sequelae such as seizures, muscle spasms, and cognitive problems. Spasticity disorders have been shown to increase the risk of multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease, among others. The neurological sequelae include cerebrovascular accidents, motor neurone disease, peripheral vascular disease, cerebral palsy, spinal cord injury, and multiple sclerosis. The most commonly reported neurological sequelae of spasticity disorders include dystonia, dysarthria, spasm, dysarthria, tremor, cerebral palsy, and myoclonus.
The exact mechanism behind the neurological symptoms associated with spasticity is not fully understood. It has been hypothesized that the neurotransmitter baclofen has a positive effect on the activity of gamma-aminobutyric acid (GABA) in the nervous system, leading to the improvement of spasticity. The effect of baclofen on spasticity has been well studied and is believed to be associated with the increase in GABA neurotransmission within the central nervous system. Furthermore, the effect of baclofen on muscle spasticity has been shown to be additive to its effect on spasticity. However, the effect of baclofen on spasticity has not been studied to our knowledge.
Spasticity is a common neurological disorder that can cause various degrees of disability and disability-for-profit care, including severe spasticity (Spinal Cord Injury, Spinal Cord Dyskinesia, Spinal Cord Injury and Spinal Cord Dyskinesia). The symptoms of spasticity associated with CP include dystonia, dysarthria, muscle spasms, and post-traumatic spasticity.
Baclofen belongs to the class of medications known asnon-selective GABAB receptor agonists. It works by increasing levels ofneurotransmitterin the brain, which can help treat conditions such as
clomipramine-induced neuropsychiatric symptoms,cholinesterase deficiency, and
neuroleptic malignant syndrome(NMS). Baclofen is used to treat conditions such as:
Baclofen is not addictive.
Take this medication by mouth with a full glass of water, approximately one hour before a meal. Your doctor will decide the dosage based on your medical condition and response to treatment.
The dose is based on your medical condition and response to treatment.
Follow your doctor's instructions regarding dosage and frequency of use.
Overdosage of this medication could cause serious problems if it is not taken right away.
If you think you have used too much of this medication, contact a poison control center at once if you notice signs of an overdose, such as confusion, seizures, or drowsiness. Symptoms of an overdose may include:
If you think you have used too much of this medication, contact your doctor at once if you notice signs of an overdose, such as an increased risk of convulsions or coma.
If you believe you have used too much of this medication, talk to your doctor at once if you have trouble breathing or swallowing, unusual tiredness, weakness, confusion, or palpitations.
If you think you have used too much of this medication, talk to your doctor at once if you have trouble breathing or swallowing, unusual tiredness, weakness, confusion, or palpitations.
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